Think tank of re-redoing the current cube to trim it down to 180 cards for a leaner, 2-4 player setup.
Drafting would probably be done as Minesweeper or Grid draft, so that players are familiar with all the cards.
Trying to cut out any shuffle effects or double-faced cards to streamline gameplay.
Current ideas:
Tempo
Drain and Gain
Sacrifice Aggro
Stompy
Ramp
Control
Self-mill
Spells
Equipments
+1/+1 Counters