Take only the strongest card that is not reprint on each set. Then make it a Microcube
So to explain this idea a bit further. The first iteration is to take single strongest card that is new on each set, and see what kind of pile it makes. I estimate that there should be enough cards for a microcube, so I'm on purpose avoiding card draw and tutors as decks will probably be of 15 cards.
As I did go ahead and added brainstorm, I'm thinking players will lose if no cards in deck, but that and if other comboes get counterparts remain to be seen as I go further in the list. Worst case scenario, I'm removing broken comboes once this is done and look for something else in that set.