Multi-colour Cube
The core of the cube is (loosely) based on the guilds of Ravnica to keep the main focus on multi-Colour, but upgraded with cards from other sets to maximize their power, options and/or Syngergy.
Some guilds have been adjusted more than others, by adding more cards outside of the sets and/or by creating another theme for the "guild".
Also weaved in the Theros Gods, to give every Guild a boost/bomb/"Leader". (some with a bigger succes than others, but then again wanted to keep up the complete cycle of Gods)
Themes are connected with the other guilds and/or mono colors. So if needed you could easily play well rounded 3-colored decks. For example: Playing W/B/R has a synergy with aristocrat, graveyard recursion and some life gain/steal (reactions). In other words; Orzov, Boros and Rakdos. Depeding on drafted cards you theme could be more Aristocrat with equipment or Vampire Aristocrat or something else.
Although 2-color is also possible and by creating more weight of the number of mono-colour cards it should be easy enough.
Main themes:
Azorius: Artifact, Control, Flying, Flicker.
Boros: Equipment, Combat tricks
Dimir: Unblockable/Evasion, Control, Discard,
Golgari: Graveyard recursion and Life steal/Gain
Gruul: Rush, Burn
Izzit: Effects on casting Instants/Sorceries, Flying, Counter, Burn
Orzhova: Reactions on Life; Steal/Gain, Aristocrat, Graveyard tricks
Rakdos: Aristocrat, Rush, Burn
Semic: Draw, +1/+1
Selesnya: populate, tokens, +1/+1
Black: Creature destruction, aristocrat, life gain/steal
Blue: Artifact, Control, Flash, Flying, draw
Green: Creatures, Ramp, Tokens,
Red: Burn, Rush, Alternative card draw/gain/casting*
White: Artifact, Life gain/steal (& reactions on life gain), Control, Equipment
*) Alternative card draw/gain/casting; (mostly) Red (but also Black/Blue) has abilities and reactions that exiles top card from the library (or Hand) and then able to cast it.