This is my multicolored cube. It's a huge amount of gold cards and pushes decks towards being 3+ colors.

Expect to draft 3+ colors.

The 3 color pairings motivate a combination of all 3 pairings.
Esper: - Artifacts
Grixis: - Flashbacking
Jund: - Sacrifice (more non-creatures, Treasures)
Naya: - Keywords matter / Dragons
Bant: - Counters Matter
Mardu: - Sacrifice
Temur - Cascade and Big things
Abzan - +1 Counters matter?
Jeskai - Spell Casting
Sultai - Graveyard Matters (differently than Abzan, though)

Architecture of 360 Cards
50 Lands (Triomes, Triomes at home, DOM lands, Bouncelands) + 5 Vivid's + 5 other.
30 Three-Color cards (3 each)
30 Artifacts
5 cards for five-color
Leaves us with 245 cards for the single colored and 2-color cards. (20ish per 2-color combo, and 45 for the regular colors)