The Syneraction Cube was created with the specific intent to try to answer the question, are synergy and interaction incompatible with one another? My initial approach to making the two more compatible is to lower the overall mana value of the cards, so that cheap interaction is much less of a blowout in terms of tempo. My second attempt at making synergy more approachable is to put the main synergy pieces in artifacts or enchantments, so they are less susceptible to removal.

Draft a deck and let me know what you think!