During any turn, activate Pestilence by paying , dealing 1 damage to each creature and each player.
Each creature your opponents control dies as a state-based action due to having 0 toughness.
Repeat each turn as desired.

This lock can be repeated multiple times during a single turn if you have mana available. However, this damage also stacks on your creatures - and if Maha dies then the lock ends. This lock will also destroy any creatures you control with toughness 1. As it does 1 damage to each player every time you activate it, you must stop once your life total hits 1.

You control a permanent that can tap to add .
You have the highest life total.

Activate the permanent by tapping it, adding .
Activate Pestilence by paying , dealing 1 damage to each creature and each player.
Cacophodon and Rite of Passage trigger.
Resolve the Rite of Passage trigger, putting a +1/+1 counter on each creature you control.
Resolve the Cacophodon trigger, untapping the permanent that can produce .
Repeat.

Vhati il-Dal and Tree of Perdition do not have summoning sickness.
Your life total is at lest two.

Activate Vhati il-Dal by tapping it, causing Tree of Perdition to have base toughness 1 until end of turn.
Activate Tree of Perdition by tapping it, swapping an opponent's life total with Tree of Perdition's toughness.
Activate Pestilence by paying , dealing 1 damage to each creature and each player.
The opponent targeted in step 2 loses the game due to having zero life.
You may repeat this during each of your turns if your life total allows.

The total number of cards in your library and hand is at least equal to the highest life total among your opponents.

Cast Angel's Grace by paying , preventing you from losing the game this turn.
Cast Ad Nauseum by paying , putting your entire library in your hand and losing life equal to the total converted mana cost of those cards.
Activate Skirge Familiar many times by discarding your entire hand, adding for each card discarded.
Actviate Pestilence many times by paying each time, dealing 1 damage to each creature and each player each time.

You have the highest life total.

Activate Pestilence by paying , dealing 1 damage to each creature and each player.
Sprouting Phytohydra triggers, creating a token copy of itself.
Activate Phyrexian Altar by sacrificing the damaged Sprouting Phytohydra, adding .
Repeat until each opponent loses the game due to having zero or less life.

Pentad Prism has at least one charge counter.
Urban Daggertooth has at least one +1/+1 counter.
You have the highest life total.

Activate Pestilence by paying , dealing 1 damage to each creature and each player.
Urban Daggertooth triggers, putting a +1/+1 counter on Urban Daggertooth and a charge counter on Pentad Prism.
Activate Pentad Prism's ability by removing a charge counter from it, adding .
Repeat.

You have the highest life total.
You control at least one basic Swamp.

Activate a basic Swamp by tapping it, adding .
Activate Pestilence by paying , dealing 1 damage to each creature and each player.
Each Polyraptor you control triggers, creating that many token copies of Polyraptor.
Activate Earthcraft by tapping an untapped Polyraptor, untapping the basic Swamp.
Repeat.

You have a way to give Vigor indestructible.
You have the highest life total.

Give Vigor indestructible by any method.
Activate Pestilence by paying , dealing 1 damage to each creature you don't control, Vigor and each player, and putting a +1/+1 counter on each other creature you control due to Vigor.
Activate Crystalline Crawler's first ability by removing a +1/+1 counter from it, adding .
Repeat from step 2.

Gemstone Array has at least one charge counter.
Urban Daggertooth has at least one +1/+1 counter.
You have the highest life total.

Activate Pestilence by paying , dealing 1 damage to each creature and each player.
Urban Daggertooth triggers, putting a +1/+1 counter on Urban Daggertooth and a charge counter on Gemstone Array.
Activate Gemstone Array's second ability by removing a charge counter from it, adding .
Repeat.

Cast Angel's Grace by paying , preventing you from losing the game this turn.
Cast Ad Nauseam by paying , putting your entire library into your hand and losing life equal to each card's mana value.
Activate Cadaverous Bloom by exiling a card from your hand, adding .
Activate Pestilence twice by paying , dealing 2 damage to each creature and each player.
Your life total is instead set to one due to Angel's Grace.
Repeat from step 3.

You have the highest life total.

Activate Pestilence by paying , dealing 1 damage to each player and each creature your opponent control.
Darien triggers, creating a 1/1 Soldier creature token.
Activate Phyrexian Altar by sacrificing the Soldier token, adding .
Repeat.

You have the highest life total.

Activate Pestilence by paying , dealing 1 damage to each player.
Darien triggers, creating a 1/1 Soldier creature token.
Activate Phyrexian Altar by sacrificing the Soldier token, adding .
Repeat.

Cast Gideon's Sacrifice by paying , causing all damage that would be dealt this turn to you or to permanents you control to be dealt to Crystalline Crawler instead.
Activate Pestilence by paying , dealing 1 damage to each creature and each player.
Gideon's Sacrifice redirects damage to Crawler, which results in at least three +1/+1 counters being placed on it instead due to Vigor.
Activate Crystalline Crawler's first activated ability at least once by removing at least one +1/+1 counter from it, adding at least .
Repeat from step 2.

Cast Saving Grace by paying .
Saving Grace enters the battlefield attached to Crystalline Crawler, triggering itself, causing all damage that would be dealt to you or permanents you control this turn to be dealt to Crystalline Crawler instead.
Activate Pestilence by paying , dealing 1 damage to each creature and each player.
Saving Grace's ability redirects damage to Crystalline Crawler, which results in at least three +1/+1 counters being placed on it instead due to Vigor.
Activate Crystalline Crawler's first activated ability at least once by removing at least one +1/+1 counter from it, adding at least .
Repeat from step 3.

Sonic has indestructible.

Activate Pestilence by paying , dealing 1 damage to each creature and each player.
Sonic triggers for each creature you control with haste or flash that is dealt damage, creating that many tapped Treasure tokens.
When the Treasure(s) enter, Amulet of Vigor triggers that many times, untapping the Treasure(s).
Activate a Treasure by tapping and sacrificing it, adding .
Repeat.

It is strongly recommended to perform this combo once you have the highest life total to end the game. It is, however, not a requirement.

Sonic has indestructible.

Activate Pestilence by paying , dealing 1 damage to each creature and each player.
Sonic triggers for each creature you control with haste or flash that is dealt damage, creating that many untapped Treasure tokens due to Archelos.
Activate a Treasure by tapping and sacrificing it, adding .
Repeat.

It is strongly recommended to perform this combo once you have the highest life total to end the game. It is, however, not a requirement.