The infamous twin combo shows up in many shapes and colors in the cube. The core of the twin combo is using an infinite loop to create an arbitrarily large number of creatures to attack and win the game with.

This combo needs a duplicator and a target. There are several of both in the cube, but not all pairs work together.

A duplicator needs to be able to make a copy of the target. The duplicator in the cube are Splinter Twin, Kiki-Jiki, Mirror Breaker, and (for the cat only) Saheeli Rai. The target need to do something that resets the duplicator, like Deceiver Exarch, Pestermite, Restoration Angel, Felidar Guardian, and Zealous Conscripts.